One of the most difficult problems in ophthalmology is the differential diagnosis between benign and malignant intraocular lesions. In addition to the usual difficulties offered in such a diagnosis in any body location, the eye presents the complicating feature that many of its lesions cannot be biopsied without irretrievable damage to the function of the organ.Since the advent of the application of radioisotopes to clinical practice there has been the great hope that the isotopes could become an important aid in diagnosis and treatment of malignancy. In ophthalmology recent years of experience have established radioactive phosphorus as a most important but not absolute test for malignancy.
Terner, Leopold, and Eisenberg1 have written an excellent review article. For the background of the use of P32 in medicine generally or ophthalmology specifically this article is highly recommended.
SHAPIRO I. Radioactive Phosphorus in Differential Diagnosis of Ocular Tumors: Special Reference to Results of University of Michigan Study, July 1954-May 1956. AMA Arch Ophthalmol. 1957;57(1):14–17. doi:10.1001/archopht.1957.00930050016004
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