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January 1957

Chordomas of Ocular Interest

AMA Arch Ophthalmol. 1957;57(1):19-23. doi:10.1001/archopht.1957.00930050023006

The existence of tumors derived from the notochord has been known for more than 100 years. In 1857, Virchow1 noted the presence of gelatinous excrescences upon the clivus of Blumenbach and, mistakenly assuming them to be of cartilaginous origin, called them "ecchordoses physaliphora." In 1858, Müller2 suggested the theory of notochordal genesis, which was supported by Ribbert,3 who produced the histological picture of noninvasive chordal tissue by puncturing the nuclei pulposi of rabbits. Ribbert also suggested the now commonly accepted terminology of chordoma.

Some discussion of the embryology of the notochord is an essential preface to the description of chordomas. The notochord, a primitive axial supporting structure of the embryo, undergoes successively greater regression as it ascends the phylogenetic ladder. In Amphioxus it persists as the

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