The Toxoplasma dye test of Sabin and Feldman,1 which is the mainstay of the present diagnostic regimen in presumptive ocular toxoplasmosis, appears to be inadequate on a number of accounts. Although Woods,* has recently shown that a serum titer of 1:64 is statistically significant in a group of adult patients with granulomatous uveitis, there is no definite proof that a given lesion in the uveal tract of such a patient is due to toxoplasmosis, as opposed to one of the other common granulomatous infections. The simultaneous existence of a positive serum dye test titer, due, perhaps, to a previous systemic infection with Toxoplasma, and a granulomatous uveitis due, for example, to tuberculosis, is a real possibility. Woods, moreover, stated that 25% of a nonuveitis control group which was studied serologically at the Johns Hopkins Hospital also showed positive dye tests at a titer of 1:64. Pursuant to a study
O'CONNOR GR. Anti-Toxoplasma Precipitins in Aqueous HumorNew Application of the Agar-Diffusion Technique. AMA Arch Ophthalmol. 1957;57(1):52–57. doi:10.1001/archopht.1957.00930050060013
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