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January 1957

Novobiocin, A New Antibiotic: Ocular Penetration and Tolerance

Author Affiliations

From the Research Department of the Wills Eye Hospital. Research Fellow in Ophthalmology (Dr. Paul).

AMA Arch Ophthalmol. 1957;57(1):100-109. doi:10.1001/archopht.1957.00930050108019

Introduction  Novobiocin is the generic name that has been adopted for two new antibiotics which were discovered independently of each other and later found to be identical. One of these, Cathomycin,* is derived from Streptomyces spheroides n. sp.,1 and the other, streptonivicin,† is derived from Streptomyces niveus n. sp.2 Early studies of the antibacterial activity of these antibiotics3 indicated a very close similarity in their activity, which led Welch and Wright4 to undertake a study of their physical properties. Close similarities of the ultraviolet and infrared absorption spectra and other physical properties of these two antibiotics showed that they were identical. Included in this work was a third antibiotic, Cardelmycin ‡ (crystallinic acid; formerly referred to as PA 93), which was also found to be identical to streptonivicin and Cathomycin. With the wide variety of names attending the independent discoveries of this antibiotic, some confusion is

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