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February 1957

Vascular Changes in Eyes of Diabetic Rats: Alterations in the Anterior Segment

Author Affiliations

Iowa City
From the Departments of Anatomy and Ophthalmology, College of Medicine, State University of Iowa.

AMA Arch Ophthalmol. 1957;57(2):218-223. doi:10.1001/archopht.1957.00930050228010

In 1952 Janes, Bounds, and Leinfelder1,2 reported on cataract formation in alloxandiabetic rats. At that time these authors observed intraocular hemorrhages in the form of hyphemas (with subsequent corneal vascularization) to have occurred in some of their animals.

These studies have been continued, and to date 30 rats have been noted to have developed hyphemas with subsequent corneal changes. The animals have been killed at various times after the development of these complications. Studies of the ocular vascular system have been made following intravascular injections of neoprene latex * or India ink. This paper describes the gross and histological changes observed.

Technique  Long-Evans strain adult male rats were fasted for 48 hours and then given a subcutaneous injection of 115 mg. of alloxan per kilogram of body weight. As previously, these rats were followed with regard to blood sugar levels, urine volumes, food intake, and body weight. Feedings consisted of

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