Iodoacetic acid (IAA) in vapor form acts as a lacrimator (Mackworth1). When applied topically or injected into the corneal stroma, severe corneal lesions and opacifications may develop (Harley2).In a series of papers, Noell3,4 presented experimental evidence that intravenous IAA exerts a selective effect on structure and function of the retina. It impairs the electroretinogram (ERG) within a few seconds following its injection and produces death of the rod cells. This effect on the receptors of scotopic vision manifests itself microscopically as pyknosis of the rod nuclei and is followed by degeneration and atrophy of the outer retinal layers.Similar to this effect of IAA on the retina are changes produced by high-intensity ionizing radiation in guinea pigs, rabbits, dogs, and monkeys.5-8 From the similarity of the retinal changes produced by IAA and ionizing radiation, the question arose whether IAA also possessed the ability to
CIBIS PA, CONSTANT M, PRIBYL A, BECKER B. Ocular Lesions Produced by Iodoacetate. AMA Arch Ophthalmol. 1957;57(4):508–519. doi:10.1001/archopht.1957.00930050520004
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