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April 1957

Ocular Lesions Produced by Iodoacetate

Author Affiliations

St. Louis
From the Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine.

AMA Arch Ophthalmol. 1957;57(4):508-519. doi:10.1001/archopht.1957.00930050520004

Introduction  Iodoacetic acid (IAA) in vapor form acts as a lacrimator (Mackworth1). When applied topically or injected into the corneal stroma, severe corneal lesions and opacifications may develop (Harley2).In a series of papers, Noell3,4 presented experimental evidence that intravenous IAA exerts a selective effect on structure and function of the retina. It impairs the electroretinogram (ERG) within a few seconds following its injection and produces death of the rod cells. This effect on the receptors of scotopic vision manifests itself microscopically as pyknosis of the rod nuclei and is followed by degeneration and atrophy of the outer retinal layers.Similar to this effect of IAA on the retina are changes produced by high-intensity ionizing radiation in guinea pigs, rabbits, dogs, and monkeys.5-8 From the similarity of the retinal changes produced by IAA and ionizing radiation, the question arose whether IAA also possessed the ability to

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