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June 1957

Ocular Metastases in Hutchison-Pepper Syndrome

Author Affiliations

Calcutta, India
From the Department of Ophthalmology, Nilratan Sircar Medical College; Professor of Ophthalmology (Dr. Das Gupta) and Associate Professor of Surgery (Dr. Roy).

AMA Arch Ophthalmol. 1957;57(6):821-831. doi:10.1001/archopht.1957.00930050833004

The purpose of this paper is to report on the involvement of various structures of the eye in a case of Hutchison-Pepper syndrome (neuroblastoma of the adrenal gland with involvement of the liver and the orbit) which underwent spontaneous retrogression. The report seems justified in view of the fact that no reference could be found in the literature in which metastatic deposits were reported in the ocular tissues. It will also add to the literature another case of spontaneous retrogression in a proved case of neuroblastoma of the adrenal gland.

Historical Review  The tumors of the adrenal gland consisting of immature pleuripotential undifferentiated neuroblasts, which are now termed neuroblastoma or sympathicoblastoma, were first described as gliomata by Virchow (1864). Subsequently they were grouped as "round-celled sarcomas" of the adrenal gland or "lymphosarcomas." A review of the previous records shows that many of such recorded tumors are of the nature of

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