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June 1957

The Effect of Cell Suspensions upon the Development of Cataracts in Irradiated Mice

Author Affiliations

From the Department of Surgery (Ophthalmology) and the Argonne Cancer Research Hospital, The University of Chicago.

AMA Arch Ophthalmol. 1957;57(6):846-848. doi:10.1001/archopht.1957.00930050860008

Cysteine, administered parenterally to rats prior to total-body irradiation, has been reported by Patt and his co-workers1 to increase the survival of the treated animals, whereas sodium chloride given before radiation or cysteine given afterwards does not. Von Sallmann2 has described a deterrent effect of cysteine administered intravenously to rabbits before a single exposure to 1500 r delivered to the eye. Jacobson and his associates3 and Lorenz et al.4 have shown that hemopoietic cell suspensions or tissue transplants given subsequent to x-radiation have a significant effect upon the survival of rats, mice, and rabbits. There have been no reports that such postirradiation treatment might influence the development of cataracts.

It was observed that postirradiation treatment with mouse embryo cells appeared to have a deterrent effect upon the development of cataracts in a single group of mice that had been exposed to 750 r total-body x-radiation as

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