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June 1957

Effect of X-Rays on Partially Shielded Lens of the Rabbit

Author Affiliations

Oxford, England
Nuffield Laboratory of Ophthalmology, University of Oxford, and Medical Research Council Experimental Radiopathology Research Unit, Hammersmith Hospital, London.

AMA Arch Ophthalmol. 1957;57(6):849-854. doi:10.1001/archopht.1957.00930050863009

Goldmann and Liechti,3 Alter and Leinfelder,1 Puntenney and Shoch,10 and von Sallmann et al.12 have shown that irradiation of the axial core of the lens does not lead to any opacity, whereas irradiation of a sector of lens including part of the periphery causes opacities in the area irradiated. These results are clear-cut and leave no doubt that damage to the periphery of the lens is the genesis of radiation opacities. A puzzling feature, however, has been that irradiation of a sector, or even of half the lens, does not produce complete opacity within the area irradiated but simply small cortical opacities, which presumably represent the immediately damaged epithelial cells and their progeny. For example, Puntenney and Shoch,10 using a dose of 4000 rad, found that irradiation of the whole eye of the rabbit produced mature cataract, in three to five months, but that irradiation

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