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July 1957

Further Studies on the Incidence of Antibiotic-Producing Micro-Organisms of the Ocular Flora

Author Affiliations

New York
From the Departments of Ophthalmology and Microbiology, Columbia University College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital.

AMA Arch Ophthalmol. 1957;58(1):66-76. doi:10.1001/archopht.1957.00940010078007

The possibility that inhibitory organisms of the "normal" microflora of superficial human tissues may be significant in resistance to or recovery from infections in these areas was suggested many years ago.1-3 Until the recent expansion of our knowledge with regard to antibiotic substances, such studies were usually somewhat indeterminate. Reexamination of the problem since that time has shed much light on the prevalence and characteristics of such antibioticproducing organisms and has provided much circumstantial evidence implicating them in resistance or recovery mechanisms. The antibiotic activities of the microflora have been especially studied in the intestinal tract4-9 and in the ocular flora.10-13 In addition, such behavior has been found to be frequent in the organisms of the nose and throat,14,15 oral cavity,16,17 and skin.18-20 Numerous antibiotics seem to be involved,3, 21-24 and many of them seem to be of polypeptide nature. These antibiotic properties

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