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August 1957

Intraocular Lesions Associated with Sickle-Cell Disease

Author Affiliations

Fort Howard, Md.
From the Departments of Ophthalmology (Dr. Kennedy) and Medicine (Dr. Cope), Veterans Administration Hospital.

AMA Arch Ophthalmol. 1957;58(2):163-168. doi:10.1001/archopht.1957.00940010175001

Recurrent intraocular hemorrhage in young adults was first described by Eales, in 1880. He reported five cases in men between 14 and 29 years of age with recurrent hemorrhages in the retina adjacent to the veins and in the vitreous. He thought that constipation and epistaxis were etiological factors. Since, that time, numerous causes have been suggested for this condition and have included calcium deficiency with diminished parathyroid secretion,2 thromboangiitis obliterans,3 septic foci,4 and tuberculosis.5

In 1930 Cook6 discussed a patient with subarachnoid hemorrhage and sickle-cell anemia in whom a retinal hemorrhage was also noted. In 1952, Edington and Sarkies7 reported two patients with sickle-cell anemia and retinal microaneurysms; one of these patients had a vitreous hemorrhage. In the year 1950, Henderson8 published 54 cases of sickle-cell anemia in which retinal hemorrhage was a presenting sign or symptom. In 1937, Harden9 reported

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