The Chairman's address before the Ophthalmic Section of the American Medical Association * testifies to the complexity of diagnosis in malignant melanoma of the uvea. Another aspect of this problem is the equally fascinating question of prognosis. When one is facing the decision of advising enucleation of a tumor-containing eye, where the other is missing or useless, or where the patient is aged or infirm, this matter of equating the degree of malignancy against life expectancy becomes a very real and pressing responsibility. It is by no means universally appreciated that these tumors are capable of a most variable and unpredictable behavior. The broad range of their activity extends from the clinically malignant but dormant tumors of unknown duration with a time fuse of unknown length, whose growth under observation is imperceptible, to the devastating malignancy which seems literally to explode with a shower of lethal metastases. These reports are submitted
ANDERSON B, O'NEILL J. Malignant Melanoma of the Uvea: Observations on Growth and Behavior, Enucleation Refused or Delayed. AMA Arch Ophthalmol. 1957;58(3):337–347. doi:10.1001/archopht.1957.00940010349004
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