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September 1957

Three Cases of Epithelial Invasion of the Anterior Chamber Treated Surgically

Author Affiliations

From the Division of Ophthalmology, Department of Surgery, University of Colorado School of Medicine.

AMA Arch Ophthalmol. 1957;58(3):396-400. doi:10.1001/archopht.1957.00940010408013

Epithelial invasion of the anterior chamber was first recognized by Collins and Cross,1 in 1892, and has since been adequately described and classified by Perera,2 Calhoun,3 Pincus,4 Maumenee and Shannon,5,6 and others. It is an uncommon but extremely serious complication of perforating wound of the eye or intraocular surgery. Untreated, it may lead to serious visual impairment or loss of the globe. Figures 1, 2, and 3, taken from pathological specimens in the University of Colorado Ophthalmic Pathology Laboratory, illustrate the epithelial downgrowth type of epithelial invasion of the anterior chamber.

These sections demonstrate the mechanism of invasion through the corneal wound into the anterior chamber. The posterior corneal surface, the angle of the anterior chamber, the anterior surface of the iris, and the vitreous face become lined with squamous epithelium. These eyes were enucleated because of intractible glaucoma as a result of obstruction of