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November 1957

Radiation Effect on Intraocular Tissues in Radon Seed Treatment of Retinoblastoma

Author Affiliations

San Francisco
From the Division of Ophthalmology, Department of Surgery (Drs. Tamler and Winter) and Department of Radiology (Dr. Toch), Stanford University School of Medicine.

AMA Arch Ophthalmol. 1957;58(5):647-654. doi:10.1001/archopht.1957.00940010665004

For some time now, ophthalmologists have been attempting to save the less involved eye in bilateral retinoblastoma with radiation therapy. The results with x-ray therapy alone have generally been disappointing. Although retinoblastoma is radiosensitive, the dose lethal to the tumor approaches the tolerance of normal structures in the posterior part of the eye and exceeds the tolerance of the structures of the anterior part of the eye.1 The relatively narrow margin between the cancericidal dose and the dose tolerated by normal ocular tissues has given rise to many complications with x-ray therapy.2 The complication of gravest concern is late vitreous hemorrhage from damaged retinal blood vessels.3 In order to reduce the incidence of complications, the dosage of x-ray has been decreased by employing along with it a radiomimetic drug, such as the nitrogen mustards4 or, especially, triethylene melamine (TEM).3 The results of this combined therapy

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