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November 1957

Fungus Keratitis (Aspergillus Fumigatus): Treatment with Nystatin (Mycostatin)

Author Affiliations

From Departments of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School.

AMA Arch Ophthalmol. 1957;58(5):695-698. doi:10.1001/archopht.1957.00940010715008

Our purpose in this communication is to report the first case of Aspergillus keratitis treated with nystatin (Mycostatin). It is also our purpose to emphasize the importance of making an etiologic diagnosis before instituting treatment in severe corneal infection.

Ley and Sanders1 recently reported three cases of severe hypopyon keratitis in all of which unidentified fungi were demonstrated on pathologic examination. The authors point out that since the introduction of antibiotics and corticosteroids the incidence of reported cases of fungus keratitis has been rising rapidly. They also stress the importance of suspecting fungus infection in cases of hypopyon keratitis and of carrying out adequate etiologic investigation. In a study of experimental fungus infection of the cornea, Ley2 showed that oxytetracycline potentiated Candida albicans infection of the immature rabbit cornea. He also showed that there was an 80% average incidence of experimental fungus keratitis in cortisone-treated eyes as contrasted

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