Leptospirosis is a spirochetal systemic disease with protean clinical manifestations. In the early phase of the disease the organisms are blood-borne and are capable of lodging in any organ or organs, including the eye. Consequently, the multiplicity and and variation of signs and symptoms are determined by the system or systems involved. The most commonly known clinical entity related to this group of organisms is Weil's disease, caused by Leptospira icterohaemorrhagiae, which has a predilection for the liver. Although jaundice commonly occurs, it is not a necessary component and is merely a manifestation of gross liver involvement, which is not present in the majority of cases. The incidence of jaundice varies, and in one series of 81 patients no jaundice was reported.1,2 However, it has been stated that there is no mortality unless jaundice is present.3
The disease has a world-wide distribution. The incidence of this disease is
ROWEN GE. Leptospiral Uveitis. AMA Arch Ophthalmol. 1957;58(5):754–757. doi:10.1001/archopht.1957.00940010776017
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.