Eosinophilic granuloma of the bone is a rare disease. It was described by Froser in 1935 and later on by Litchenstein and Jaffe6 in 1940. Children and young adults are most often affected. General health is unimpaired. Sometimes there is low-grade pyrexia, but usually there is absence of any systemic disturbance. The lesions are Situated in the flat bones, e. g., ribs, pelvis, or skull. Occasionally the long bones show the deposits. In fact, any bone, with the possible exception of those of the hand and feet, may be involved. The affected bone is rarefied, and its shell is expanded. The lesions are moderately tender; there is slight or dull pain. When the affected bone is in the vicinity of a joint, its movements are restricted. Involvement of liver, spleen, and cerebral structures has also been reported.
Exophthalmos produced by an eosinophilic granulomatous lesion in the orbit is a
NIRANKARI MS, SINGH M, MANCHANDA SS, CHITKARA NL, MAUDGAL MC. Eosinophilic Granuloma of the Orbit. AMA Arch Ophthalmol. 1957;58(6):857–861. doi:10.1001/archopht.1957.00940010879007