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January 1958

Treatment of Experimental Herpes Simplex Iridocyclitis with Human Serum Gamma-Globulin

Author Affiliations

Howe Laboratory of Ophthalmology, Harvard University Medical School, Massachusetts Eye and Ear Infirmary.

AMA Arch Ophthalmol. 1958;59(1):68-72. doi:10.1001/archopht.1958.00940020094009

Herpetic infection of the eye constitutes one of the commoner and less responsive therapeutic problems faced by the ophthalmologist. The incidence and clinical features of this disease were catalogued by Gundersen1 in his classic paper published more than 20 years ago. Thygeson, Kimura, and Hogan2 have reviewed recent developments and have set forth the current status of the problem of herpes oculi. From these studies, it appears that herpes corneae may actually be increasing in frequency, that its complications are increasing in severity (partly as a result of injudicious treatment with corticosteroids), and that no specific chemotherapy exists for this disease.

The ecology of herpes simplex virus in human beings has been elucidated by Burnet3 and has been reviewed by Blank and Rake.4 Antibody surveys of various populations have shown a neutralization of herpes simplex by the sera of high percentages of persons. Uniformity of antiherpes

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