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January 1958

Comparative Studies on Anesthetic Properties of Primacaine HCI

Author Affiliations

From the Department of Ophthalmology, Hospital of the University of Pennsylvania, and The Children's Hospital of Philadelphia.

AMA Arch Ophthalmol. 1958;59(1):81-87. doi:10.1001/archopht.1958.00940020109011

This paper presents the results of clinical and experimental work comparing a new local anesthetic agent, 2'-diethylaminoethyl 2-butoxy-3-aminobenzoate (Primacaine) hydrochloride* to certain other local anesthetics in common use, particularly from the standpoint of duration of effect. It is the third paper from our department reporting work started in 1951 in an attempt to find a local anesthetic of sufficient duration to avoid the period of acute postoperative pain which occurs during the first few hours after ocular surgery.1,2 Primacaine hydrochloride was recently made available to us as a local anesthetic agent. It has low toxicity, great potency, and a somewhat longer duration than other anesthetics currently available.3,4

Scheie et al.,1 in 1952, reviewed the literature on long-lasting local anesthetics and pointed out the advantages which would accrue from local anesthesia of sufficient duration to avoid postoperative pain in ocular surgery. Much restlessness, nausea, and vomiting, all of

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