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March 1958

Accommodation-Convergence Association: Experiments with Phenylephrine, Pilocarpine, and Physostigmine

Author Affiliations

Rochester, Minn.
Abridgment of thesis submitted by Dr. Sabin to the Faculty of the Graduate School of the University of Minnesota in partial fulfillment of the requirements for the degree of Master of Science in Ophthalmology.; Fellow in Ophthalmology, Mayo Foundation (Dr. Sabin), and Section of Biophysics and Biophysical Research, Mayo Clinic and Mayo Foundation (Dr. Ogle). The Mayo Foundation, Rochester, Minn., is a part of the Graduate School of the University of Minnesota.

AMA Arch Ophthalmol. 1958;59(3):324-332. doi:10.1001/archopht.1958.00940040030002

Introduction  In a recently published paper1 data were described which showed that the amount of convergence associated with a given change in the dioptric stimulus to accommodation is greatly increased when the eyes are under cycloplegia induced by homatropine over that when they are in the normal state. This phenomenon was first described by Maddox and more recently by Morgan.2 As measured quantitatively, homatropine causes a marked increase in the accommodative convergence-accommodation (stimulus) ratio [(A — C)/A] over that ratio measured normally. The increase seems to vary as a function of the degree of cycloplegia. The data were obtained by the fixation-disparity technique. With this technique of measuring ocularmotor imbalance, extrafoveal binocular vision and fusion are maintained throughout the test and both eyes are subjected simultaneously to the same dioptric stimulus to accommodation. Most interestingly, the data showed that in the presence of homatropine cycloplegia the change in

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