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March 1958

Experimental Studies on Cx-Reactive Protein in Rabbit Aqueous

Author Affiliations

Philadelphia With the Technical Assistance of Kathryn Tomikawa

AMA Arch Ophthalmol. 1958;59(3):389-405. doi:10.1001/archopht.1958.00940040095011

Preliminary studies (Wolkowicz, Hallett, and Leopold14) on the possible role C-reactive protein might play in ocular pathology suggested that the C-reactive protein (CRP) test, when applied to the aqueous humor, may shed some additional light on the etiology and differential diagnosis of uveitis. The following data are pertinent to the present study.

C-reactive protein is found consistently in sera of patients suffering from an active inflammatory or necrotizing process, not so consistently in cases of rheumatoid arthritis, virus infection, and active tuberculosis (Roantree and Rantz10).

C-reactive protein, unlike the usual antibody, appears in the early stage of infection, and its titer declines when antibodies tend to appear, during the convalescing period (Perlman et al.9).

Comparative electrophoretic studies of CRP and antibody to C-polysaccharide showed that the former seems to migrate with the α-globulin fraction, whereas the latter is found in the γ-globulin group. Perlman et al. conclude

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