From 1948 to 1954 a series of papers on the effect of various antibacterial agents on experimental ocular tuberculosis appeared from the Wilmer Institute. These various studies have indicated that streptomycin is the one antibiotic thus far discovered with a strong antibacterial action against Mycobacterium tuberculosis. A number of the synthetics—glucosulfone (Promin), thiazosulfone (Promizole), aminosalicylic acid, and isoniazid—also have a specific antibacterial effect on the bacillus. This varies from a moderate bacteriostatic up to an actual bactericidal effect. It was further shown in these experimental studies that when streptomycin is used in combination with one of the synthetics as an adjuvant the antibacterial and therapeutic result is much greater than would be expected by a mere additive effect. It suggested a synergetic action of the two therapeutic agents. It was also shown that the use of these agents in combination inhibited to a considerable extent the development of bacterial resistance.
WOODS AC, WOOD R, SENTERFIT LB. Studies in Experimental Ocular Tuberculosis: XVIII. The Effect of Cortisone Combined with Specific Antibacterial Therapy on Experimental Ocular Tuberculosis in the Immune-Allergic Rabbit. AMA Arch Ophthalmol. 1958;59(4):559–578. doi:10.1001/archopht.1958.00940050115014
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