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May 1958

Effect of Different Steroids on the Healing of Nonperforating Corneal Wounds in Rabbits

Author Affiliations

San Francisco
Department of Ophthalmology, Ramakrishna Mission Sevashrama, Vrindaban, U. P., India; Colombo Plan Fellow in Canada; Department of Ophthalmology and the Francis I. Proctor Foundation for Research in Ophthalmology, University of California School of Medicine.

AMA Arch Ophthalmol. 1958;59(5):657-664. doi:10.1001/archopht.1958.00940060041003

Because of the reports of the inhibitory action of corticosteroids on wound healing, many eye surgeons have hesitated to use them during the immediate postoperative period and have been reluctant to perform corneal surgery on patients who are under steroid therapy. Others, however, are of the opinion that steroids do not prevent corneal healing when used within the therapeutic dosage.

In histologic studies, Ashton and Cook1 observed inhibition of healing in perforating corneal lesions in rabbits treated with a high dose of cortisone subconjunctivally. Newell and Dixon2 studied the healing process of penetrating corneal grafts in rabbits both clinically and microscopically and found that cortisone given subconjunctivally delayed wound healing through failure of fibroblastic proliferation. By testing the tensile strength of the incisions and by histological sections, Palmerton3 showed that topically administered cortisone caused inhibition of healing of penetrating corneal wounds in rabbits. McDonald and coworkers4

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