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May 1958

Secondary Degeneration of the Human Retina: Pathological Study of the Retina in a Case of Secondary Glaucoma and Chronic Uveitis with Use of a New Technique

Author Affiliations

Ann Arbor, Mich.
From the Laboratories of Neuropathology and Neuro-Ophthalmology and from the Department of Ophthalmology of the University of Michigan.

AMA Arch Ophthalmol. 1958;59(5):731-745. doi:10.1001/archopht.1958.00940060115014

The silver carbonate methods of del Rio Hortega make it possible to visualize normal and pathological structures of the human retina which are not accessible with the conventional histological techniques.1-4 It is therefore necessary to reexamine with these methods many abnormal situations of the eye the pathology of which has become well known by use of the conventional techniques.

This paper intends to present such an examination of a long-known pathological situation of the human retina: advanced secondary degeneration. It demonstrates the advanced degenerative changes of the retinal neurons and astroglia in a case of secondary glaucoma and chronic uveitis following injury. In this case the silver carbonate methods show the known histological findings in a new light and also enable us to demonstrate completely new pathological changes. The nature and significance of most of these changes is not yet understood, but it is hoped that their detailed description

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