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May 1958

The Electronic Integrator for Quantitative Definition of Biological Curves

Author Affiliations

Hôpital de la Pitie 83, Blvd. de l'Hôpital Paris 13.

AMA Arch Ophthalmol. 1958;59(5):803-804. doi:10.1001/archopht.1958.00940060187018

To the Editor:  —I read with great interest the paper entitled "Quantitation of Extraocular Muscle Innervation," by G. M. Breinin, published in the May, 1957, issue of the A. M. A. Archives of Ophthalmology. It appears to me that the author does not seem to be aware of certain number of facts.

  1. In 1937 I suggested1 and since then have used integration as the only adequate method for a quantitative evaluation of irregular biological curves, especially for EEG records. This proposal has been accepted by other authors, mainly by H. Berger, creator of modern EEG, and has been used in their research work.2 However, the integration technique, which is laborious, is difficult to use.

  2. Since 1939 I have used successively different electrical and electronic systems of integration.3-8

    • The first apparatus, built in 1938, seems to be identical with Breinin's. A condenser being charged by the rectified voltage

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