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June 1958

Reactions of the Cellular Elements of the Corneal Stroma: A Report of Experimental Studies in the Rabbit Eye

Author Affiliations

Ann Arbor, Mich.
From the Laboratories of Neuropathology and Neuro-Ophthalmology and from the Department of Ophthalmology, University of Michigan.

AMA Arch Ophthalmol. 1958;59(6):873-881. doi:10.1001/archopht.1958.00940070087010

Up to the present time there seems to be some confusion about the nature, the origin, and the significance of the reactive forms of corneal cells under pathological conditions. The present paper represents an effort to demonstrate the main phases of the nonspecific cellular reactions of the cells of the corneal stroma. These reactions of the stroma cells will be compared with those of the cellular elements which invade the corneal stroma from the limbus. The cornea of the rabbit was chosen for this experimental study, since the histological slides of this tissue allow for a detailed photomicrographic recording of all its cells and their pathological changes. Furthermore, it is my impression that the reactions of the cells of the rabbit cornea are very similar to those in man.

Experimental Methods and Histological Technique  Corneae of normal rabbits were injured with (1) keratome incision, (2) keratome incision and bacterial infection,

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