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June 1958

Autonomic Imbalance and the Hypothalamus: Implications for Physiology, Medicine, Psychology and Neuropsychiatry.

AMA Arch Ophthalmol. 1958;59(6):979. doi:10.1001/archopht.1958.00940070193023

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Between the opening quotation of the preface ("Only lunatics can be completely original") to the closing quotation of the epilogue ("It is sufficient to have attempted great things") is an experimental evaluation of the state of hypothalamic balance in animals and human subjects. Although monographs have appeared on other aspects of the autonomic nervous system, this is the first attempt in the correlation of afferent autonomic impulses with efferent autonomic activity at the level of the hypothalamus. This has imposed on the author the unavoidable difficulties of selecting the proper types of autonomic impulses (intravenous Mecholyl, arterenol, sciatic nerve stimulation, etc.), the most informative measurements of autonomic activity (heart rate, blood pressure, contraction of nicitating membrane, intestinal motility, etc.), and destructive procedures on the hypothalamus (direct injections of various drugs). The results of simultaneous application of various types of stimuli is slightly confusing, but the author generously helps the reader

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