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July 1958

The Sources of Fibroblasts in Corneal Wound Repair: A Quantitative Analysis

Author Affiliations

New York
Department of Ophthalmology, Columbia University College of Physicians and Surgeons.

AMA Arch Ophthalmol. 1958;60(1):93-109. doi:10.1001/archopht.1958.00940080107014

The present study has been undertaken to determine quantitatively the extent to which transformation of corneal stromal cells and mitosis of these cells supply the healing wound with fibroblasts.* Previous investigations of the morphology of corneal wound healing have shown that most of the corneal stromal cells originally present at the wound edge were transformed into fibroblasts during the first 24 postoperative hours.1 However, by inspection alone it appeared that there were not enough corneal stromal cells present at the wound edge to account for the increased numbers of fibroblasts to be found as wound healing progressed. Furthermore, Allgöwer2 has stated that the early and great concentration of cells surrounding a wound cannot be attributed to cell division.

In this report evidence is presented to show that corneal-cell transformation and division provide for about 35% of the total number of fibroblasts found 60 hours after injury and that

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