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August 1958

Angular Blepharoconjunctivitis and Pyridoxine (Vitamin B6) Deficiency

Author Affiliations

Hirosaki, Japan
Department of Ophthalmology, School of Medicine, Hirosaki University.

AMA Arch Ophthalmol. 1958;60(2):303-311. doi:10.1001/archopht.1958.00940080319019

Introduction  Symptoms due to pyridoxine (vitamin B6) deficiency in experimental animals have been known to a certain extent. As to the symptoms in man, Mueller1 was the first who, by giving deoxypyridoxine, developed them. Since then, Schreiner,2 Vilter,3 and other researchers have reported on this subject. In the field of ophthalmology, however, experimental reports on this subject are very few and the symptoms are still indefinitely known.We made the following pyridoxine-deficiency experiments with rats and rabbits in order to observe both general and ocular changes and to compare the affections to those found in human eyes.

Experimental Method  As experimental animals 25 rats and 25 rabbits were used; in addition, 5 animals of each kind were prepared for controls.

  1. Rats.—They were young and rather weak, from 40 to 70 days old, and weighed from 50 to 100 gm.

    Feeding: The feeding box was 23

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