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September 1958

Corneal Donor Selection by Blood Type

Author Affiliations

Columbus, Ohio
Department of Ophthalmology, The Ohio State University. Acting Chairman (Dr. Havener); Assistant Professor (Dr. Stine).

AMA Arch Ophthalmol. 1958;60(3):443-447. doi:10.1001/archopht.1958.00940080461014

Technical perfection of the procedure of corneal transplantation has reached a point where mechanical difficulties are insignificant as a cause of graft failure in an uncomplicated case. Nevertheless, an excessively large proportion of corneal grafts become opaque during the first several months following surgery. Some type of tissue intolerance has been postulated as the cause of this delayed opacification.

That some grafts remain clear and some do not suggests the possibility of matching donor with recipient in some way, thereby achieving a higher proportion of successful transplants. It is well recognized that matching of donor and recipient by blood type is essential in avoiding transfusion reactions. Blood type antigens and antibodies have been demonstrated to exist in cornea and aqueous, respectively. At the present time, however, it is not customary for the eye banks to make any attempt at matching blood types of donor and recipient.

For over two years

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