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October 1958

Differentiation, Metabolic Organization, and Viability of the Visual Cell

Author Affiliations

Roswell Park Memorial Institute.

AMA Arch Ophthalmol. 1958;60(4):702-733. doi:10.1001/archopht.1958.00940080722016


  • Introduction

  • Methods

  • Visual Cell Differentiation to a Functional State

  • Respiratory and Glycolytic Changes During Postnatal Development

  • Recent Findings on Structure and Histochemistry of the Visual Cell

  • Visual Cell Death from Poisons

  • Phenomena Related to Iodoacetate Effect

  • Effects of Oxygen Poisoning and X-Radiation

  • Changes with Age in Cytocidal Effects

  • ERG Phenomena from Effects of Poisons

  • Degeneration of the Sensory Organelles

  • Hereditary Visual Cell Death in the C3H Mouse

In this paper I should like to review mainly studies of our laboratory on the physiology of the mamalian visual cell. These studies attempt to uncover the functional and metabolic organization of the visual cell as a unit and to determine consequences of this organization with regard to visual cell disease. Experimental approaches in this direction are most timely in view of the rapidly growing background of knowledge on structure and metabolism of cells in general and especially in view of the

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