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January 1959

Streptococcal Serology in Uveitis

Author Affiliations

From the Department of Research, Wills Eye Hospital.

AMA Arch Ophthalmol. 1959;61(1):79-83. doi:10.1001/archopht.1959.00940090081011

The etiologic role of the streptococci in uveitis is predicated upon the high rate of association of endogenous uveitis, particularly of the nongranulomatous variety, with chronic foci of infection and with rheumatoid arthritis. The streptococci are the organisms most frequently found in foci and are the organisms usually responsible for the bacterial hypersensitivity displayed by rheumatoid arthritics.1

The dearth of clinical ocular tissue for direct laboratory examination makes us more dependent upon skin tests and serological studies for relating streptococcal infection to uveitis. Using both autogenous and 59 immunologically distinct stock streptococcal vaccines, Woods1,2 found skin hypersensitivity in 85% of patients with nongranulomatous uveitis and in 27% of those with granulomatous uveitis. The objection has been raised, however, that this study did not form a random series and that it included a higher proportion of patients with a poor prognosis or recurrent attacks.3

Evidence of foregoing streptococcal

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