In earlier studies my co-workers and I were able to demonstrate that hyaline bodies (corpora amylacea) of the human retina and optic nerve are a rather nonspecific finding. They may develop in senescense and under pathologic conditions from continuous or interrupted degenerating neurites (nerve fibers).1-5 Very similar bodies are found as a result of degeneration of retinal astroglia,6 perivascular glia,7 or ganglion cells8 under severe pathologic conditions. They may also occur as the final stage of hyalinization of microaneurysms in diabetic retinopathy.2,9 The hyaline bodies of these different origins look histologically very much alike. They all are eosinophilic and may show a distinct lamellation. This latter fact gives them sometimes a cell-like appearance.
It is the purpose of this paper to describe a case which exhibits all stages of a hitherto unknown type of hyaline body formation by slow degeneration of certain ganglion cells of
WOLTER JR. Hyaline Bodies of Ganglion-Cell Origin in the Human Retina. AMA Arch Ophthalmol. 1959;61(1):127–134. doi:10.1001/archopht.1959.00940090129018
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.