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April 1959

Corneal Crystals in Multiple Myeloma

Author Affiliations

Bethesda, Md.
From the Ophthalmology Branch, National Institute of Neurological Diseases and Blindness (Dr. Aronson), and the General Medicine Branch, National Cancer Institute (Dr. Shaw), National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare.

AMA Arch Ophthalmol. 1959;61(4):541-546. doi:10.1001/archopht.1959.00940090543007

Bilateral crystal-like deposits in the clear cornea or in the cornea and conjunctiva have received renewed attention in recent years, since it has become known that this clinical picture can denote such serious systemic diseases as cystinosis and multiple myeloma. Whereas adequate information is available on appearance, composition, and diagnostic value of such crystals in these ocular tissues of children with cystinosis, the nature and significance of similar deposits in patients with multiple myeloma awaits clarification. The uncertainty of the medical diagnosis in earlier case reports, the small number of pertinent observations, and the lack of histological identification of the crystals indicate that further studies on patients with multiple myeloma are warranted.

The patient described in this paper shares some of the features of the few previous cases and, thus, strengthens the diagnostic merit of the biomicroscopically visible signs. This patient also exhibits some changes which have not been recorded

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