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April 1959

The Effect of Prednisolone upon the Absorption of Hyphema in Rabbit Eyes

Author Affiliations


AMA Arch Ophthalmol. 1959;61(4):631-632. doi:10.1001/archopht.1959.00940090633019

Benedict and Hollenhorst have reported that subconjunctivally administered cortisone delays the absorption of hyphema in rabbit eyes. Although a definite difference was found in the rates of absorption in the treated and untreated animals, so few eyes were used (four eyes each for the control and noncontrol series) that it seemed worth while to repeat this experiment in a larger number of animals. Since these authors noted some physical irritation secondary to the subconjunctival injection of cortisone, intramuscular injections were made in our series. Clinically, prednisolone* is now more frequently used by us than cortisone; therefore prednisolone was used in the present experiment.

Procedure  Adult white rabbits were anesthetized with open-drop ether. From the marginal ear vein, 0.4 cc. of blood was withdrawn in a tuberculin syringe with a 25-gauge hypodermic needle. The right eye was then proptosed and grasped at the limbus with a fixation forceps. The anterior chamber

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