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April 1959

Mucopolysaccharide Sulfate in the Cornea and Sclera of Rabbits: A Study of the Normal State and After Keratoplasty

Author Affiliations

New York
From the Department of Ophthalmology, New York University-Bellevue Medical Center.

AMA Arch Ophthalmol. 1959;61(4):641-646. doi:10.1001/archopht.1959.00940090643021

As mucopolysaccharides are an important constituent of ground tissue,1 further knowledge of their properties is of great importance to the understanding of the nature of this tissue. Ocular tissues are rich in mucopolysaccharides, particularly cornea, lens capsule, and vitreous.1,2

The turnover of mucopolysaccharides in tissues can be studied with radioactive sulfate tracers. Dohlman and Boström3 demonstrated that the normal uptake and elimination of the mucopolysaccharide sulfate of the corneal stroma differed markedly from that of the sclera. Dohlman4 investigated the chemical distribution of radioactive S35 among the various sulfate components in different tissues of the rabbit eye. He demonstrated that a large amount of the sulfate in the cornea and sclera occurred as sulfomucopolysaccharide. In vitro studies5 have demonstrated the uptake by the rabbit cornea of radioactive S35 at a rate comparable to rabbit costal cartilage and the subsequent localization of this sulfate

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