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May 1959

Internuclear Ophthalmoplegia: A Review of Fifty-Eight Cases

Author Affiliations

Howe Laboratory of Ophthalmology, Harvard University Medical School.; Fellow in Ophthalmology (Dr. Smith), Special Traineeship BT-357, National Institute of Neurological Diseases and Blindness.

AMA Arch Ophthalmol. 1959;61(5):687-694. doi:10.1001/archopht.1959.00940090689003

The syndrome of internuclear ophthalmoplegia is a characteristic disturbance of ocular motility which has considerable value in topical and etiologic diagnosis. It has been described a number of times, but we are not aware of a comprehensive study of the associated clinical findings or of a determination of the prognosis. Classification of the entity has also been somewhat obscured by varying terminology in the literature. The purpose of this report is to discuss briefly the nomenclature of this syndrome and to present the ophthalmologic and neurologic findings in a series of 58 cases of internuclear ophthalmoplegia.

Nomenclature  Lhermitte,1 in 1922, is cited2 as the first to use the term "ophthalmoplegia internuclearis." However, Leslie Paton,3 in 1921, had stated, "the dorsal longitudinal bundle is of such great clinical importance that I have ventured in the classification of ocular palsies to put in a separate class of 'internuclear palsies.'

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