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May 1959

The Lattice Type of Familial Corneal Degeneration: A Histopathologic Study

Author Affiliations

Philadelphia; Iowa City
From the Departments of Ophthalmology, Hospital of the University of Pennsylvania; Veterans Administration Hospital, Philadelphia, and State University of Iowa.

AMA Arch Ophthalmol. 1959;61(5):712-719. doi:10.1001/archopht.1959.00940090714007

Corneal tissue obtained after penetrating keratoplasty from two patients with the rare lattice type of familial corneal degeneration have provided the material for this histopathologic study. Although the clinical and biomicroscopic characteristics of this type of corneal degeneration are well known, only two reports of the histologic changes can be found in the English literature,1,2 and in one of these2 the nature of the degeneration remains in doubt.

Some authors3,4 have contended that all types of familial corneal degeneration are of similar origin, since different forms have been seen in the same family. Furthermore, the histologic picture of the lattice type of corneal dystrophy appears to differ only quantitatively from that of the commoner nodular type. Dimmer,5 who published his clinical description of this entity in the same year as Haab,6 prepared a scraping from the cornea of one of his patients and found an

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