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July 1959

A Comparison of the Influence of Parenteral Trypsin, Cortisone, and Heparin on Acute Inflammation

Author Affiliations

Baltimore; Springfield, Mass.
From the Wilmer Ophthalmological Institute of The Johns Hopkins Hospital and University, Baltimore.

AMA Arch Ophthalmol. 1959;62(1):112-116. doi:10.1001/archopht.1959.04220010116013

Reports have recently appeared in the literature concerning the effectiveness of parenterally administered trypsin in the suppression of inflammation in a variety of inflammatory and thrombotic diseases. Innerfield and his associates presented "clinical observations based on 6,456 trypsin infusions to 538 patients supporting the view that trypsin rapidly suppresses acute inflammation of diversified origin (bacterial, viral, allergic, and chemical)."1 Specifically mentioned in this study were 12 cases of thrombosis of the central retinal vein which after trypsin therapy showed subsidence of retinal edema in 24 to 48 hours; 5 cases of acute iridocyclitis all showed dramatic improvement of symptoms. Hopen,2 in a study devoted to acute ocular inflammatory and thrombotic disturbances, reported impressive results in 7 of 11 cases refractory to cortisone and stated, "trypsin initiates biochemical reactions which result in prompt and sustained subsidence of acute inflammation."

Taylor, Overman, and Wright,3 as the result of an

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