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September 1959

Experimental Ocular Infection with Nocardia Asteroides in the Normal Rabbit

Author Affiliations

Dr. McCarthy now is a Resident in the Department of Ophthalmology, Cook County Hospital, Chicago.; From the Departments of Ophthalmology and of Anatomic Pathology, The Cleveland Clinic Foundation, and The Frank E. Bunts Educational Institute.

AMA Arch Ophthalmol. 1959;62(3):425-433. doi:10.1001/archopht.1959.04220030081012

Intraocular infection with Nocardia asteroides has not been reported in various extensive reviews of and experiments in ocular mycology,1-5 but we believe that it is important to understand the ocular pathologic changes caused by infection with this fungus, because of its similarity both morphologically and pathologically to Mycobacterium tuberculosis.6 Also, because fungous infections of the eye appear to be increasing in incidence as a result of the widespread use of topical antibiotics and corticosteroids.7-9 It has been estimated that 5% of all patients in tuberculosis hospitals have nocardiosis that mistakenly has been diagnosed as tuberculosis.10

The purpose of this paper is to present the intraocular pathologic findings in the normal rabbit after experimental infection of the eyes with N. asteroides.

Nocard,11 in 1888, isolated and described the species Nocardia farcineux which caused "la maladie des boeufs de la Guadeloupe," a lymphatic and visceral disease of