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November 1959

Prevention of Herpes Corneae in Rabbits

Author Affiliations

Berwick, Pa.

AMA Arch Ophthalmol. 1959;62(5):782-784. doi:10.1001/archopht.1959.04220050044007

Herpes corneae is a common eye disease, and it is often a disabling one. For years much has been written about the interrelationships of the viruses of herpes simplex, herpes zoster, and varicella. Herpetic lesions of the cornea were always intriguing to me for several reasons: They did not respond well to therapy; they occurred often in children; they were usually unilateral, and after some years they seemed to have lost their original severity. More importantly, only rarely had I ever seen a patient who had had a varicella with severe skin manifestations who thereafter had herpes labialis or herpes corneae or herpes zoster. The thought occurred that perhaps there might be some cross immunization and that infections with varicella virus were protective against herpes infections.

More than 90% of the population over 15 years of age possess neutralizing antibodies to herpes virus. Only a small group of the immunizing

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