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November 1959

Progressive Multifocal Leukoencephalopathy

Author Affiliations

Current address: 900 Lenton Ave., Baltimore 12, Md.; From the Howe Laboratory of Ophthalmology, Harvard University Medical School, Massachusetts Eye and Ear Infirmary.

AMA Arch Ophthalmol. 1959;62(5):828-832. doi:10.1001/archopht.1959.04220050090014

Astrom, Mancall, and Richardson1 have recently directed attention to progressive multifocal leukoencephalopathy, a previously unrecognized neuropathological entity. Visual symptoms have been prominent in this disorder. As no cases have been reported in the ophthalmologic literature, the following instance of progressive multifocal leukoencephalopathy substantiated by biopsy is presented.

Report of Case  The patient was seen through the courtesy of Dr. Raymond D. Adams. This 57-year-old white right-handed male garage operator was admitted to the Massachusetts General Hospital for the first time on July 23, 1958, because of confusion and memory loss of three weeks' duration. But for some fatigability during the preceding two months, he had enjoyed perfect health. However, three weeks prior to admission, when he returned home from a trip in his wrecker, the patient was noted by his wife to be in a confused state, with no clear recollection of where he had been that afternoon. In