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December 1959

Early Changes in the Lens Epithelium After Roentgen Irradiation: A Correlated Light and Electron Microscopic Study

Author Affiliations

Bethesda, Md.
From the Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare.

AMA Arch Ophthalmol. 1959;62(6):977-984. doi:10.1001/archopht.1959.04220060049009

Introduction  The ultrastructure of the normal lens epithelium has only recently been described.1 On the basis of this report it was possible to investigate the cytopathology of this cell layer in various forms of experimental cataracts with the electron microscope. It is of particular interest to follow the effects of ionizing radiations, since it has been shown that injury to the epithelium is an important pathogenetic factor in the development of radiation cataract.2-6 Previous light microscopic studies on whole mounts of lens epithelium have provided quantitative data on incipient radiation damage to the cell nucleus and established the time sequence of such changes on a cellular level.4-6In the present work, changes of the fine structures of the lens epithelial cells induced by an ionizing radiation are described at selected time intervals and correlated With results of light microscopic examinations.

Material and Methods  Both eyes of eight

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