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December 1959

Oral Urea as an Osmotic Ocular Hypotensive Agent

Author Affiliations

New York
From the Department of Surgery (Ophthalmology), New York Hospital-Cornell Medical Center.

AMA Arch Ophthalmol. 1959;62(6):1099-1100. doi:10.1001/archopht.1959.04220060171013

The use of osmotic agents in the treatment of all types of glaucoma has recently received impetus from the introduction of urea into clinical ophthalmology.1 The theoretical superiority of this drug as compared to previously used osmotic solutions has been well substantiated. Its low molecular weight, relatively poor ocular penetrance, and inertness make it eminently successful as an ocular hypotensive agent. However, though the effects of oral urea have been reported,2 most studies have dealt with the intravenous route of administration. Furthermore, no discussion has appeared relating intraocular pressure to oral urea administration. Consequently, with this latter thought in mind, the present study was undertaken.

Materials and Methods  Patients were obtained from the glaucoma clinic of The New York Hospital. Early pilot experiments revealed that absorption of the material was excellent, and that high blood levels could be obtained. A dosage level of 1.5 gm. per kilogram was

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