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March 1960

Immunological Studies with I131 Labeled Antigen in Experimental Uveitis

Author Affiliations

New York
From the Department of Ophthalmology, New York University—Bellevue Medical Center.

AMA Arch Ophthalmol. 1960;63(3):515-539. doi:10.1001/archopht.1960.00950020517010

Introduction  While the changes in ocular tissues in uveitis have been attributed to allergic reactivity, evidence for such an assumption rests on an insecure foundation. Nevertheless, from clinical experiences and investigations it appears highly probable that hypersensitivity does play a significant role in the pathogenesis of the disease.1,2 The present work is an attempt to use tracer methods in a study of the sequence of events involved in the development of experimental ocular allergic inflammatory reaction in rabbits. Various stages and aspects of this study, such as the fate of the antigen in the eye, in the circulation, its excretion in the urine, appearance of the clinical inflammatory reaction and precipitating antibodies, and the histologic and autoradiographic studies, have been correlated into a composite picture.Since Nichol and Abt3 induced an iritis in guinea pigs with horse serum, the great majority of subsequent investigators have employed the same

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