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May 1960

Uveitis Accompanied by a Positive Toxoplasma Dye Test

Author Affiliations

Bethesda, Md.
From the Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare.

AMA Arch Ophthalmol. 1960;63(5):767-773. doi:10.1001/archopht.1960.00950020769004

The occurrence of chorioretinitis in cases of congenital toxoplasmosis led to the suspicion that Toxoplasma might be responsible for ocular disease in adults, and Frenkel, in 1949,1 using the skin test, first found a correlation between posterior uveitis and sensitivity to toxoplasmin. The painstaking histological studies of Wilder, in 1952,2 revealed Toxoplasma-like organisms in the retina in cases of adult uveitis, and Jacobs, Cook, and Wilder3 confirmed the identification of these organisms by demonstrating dye test antibodies to Toxoplasma. Their work showed also that despite the occurrence of Toxoplasma uveitis, dye test titers need not be high. Wilder's histological findings have been confirmed by Duke-Elder, Ashton, and Brihaye-Van Geertrugyden.4 The isolation of the parasite from a human eye first by Jacobs et al.5 and later by others has further linked toxoplasmosis with uveitis. Extensive antibody surveys by Woods, Jacobs, Wood, and Cook,6 and by