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June 1960

Methyl- and Fluoro-Substituted Prednisolones in the Blood and Aqueous Humor of the Rabbit: Concentrations

Author Affiliations

From the Research Department, Wills Eye Hospital.

AMA Arch Ophthalmol. 1960;63(6):943-947. doi:10.1001/archopht.1960.00950020945008

Introduction  The present investigation was undertaken to study the penetration of methyl- and fluoro-substituted prednisolone compounds into the aqueous humor of the rabbit eye and their concentration in the plasma.Clinical and experimental studies upon prednisolone indicated it to be two to four times more potent than hydrocortisone, while not possessing some of the undesirable side effects associated with earlier steroids. The methyl- and fluoro-substituted prednisolones are reported to be 15-30 times more potent than hydrocortisone and 4-7 times more potent than prednisolone with respect to their anti-inflammatory and antiallergic properties.

Experimental Data  Adult pigmented rabbits were employed, each weighing 5-6 lb. Prior to tapping the anterior chamber, each eye was anesthetized with 1 drop of a 0.5% solution of pontocaine hydrochloride and then washed with isotonic saline. Removal of the aqueous humor was accomplished by means of a 26-gauge needle attached to a tuberculin syringe. When the steroid content

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