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June 1960

The Middlebrook-Dubos Test in Uveitis

Author Affiliations

From the Department of Research, Wills Eye Hospital.

AMA Arch Ophthalmol. 1960;63(6):1016-1017. doi:10.1001/archopht.1960.00950021018019

In the past 20 years tuberculosis has been rapidly losing its importance as a causative agent of uveitis. In 1941, Woods1 found 79% of granulomatous uveitis was due to tuberculosis but only 23% in 1954.2 In 1957, Stanworth3 found a further reduction to 5%, and in 1958 we4 uncovered a mere 4%. Pulmonary tuberculosis is similarly dwindling: in 1937 newly reported cases in the general population were about 87 per 100,000, which fell to 40 per 100,000 in 1957.5 Other granulomas, particularly toxoplasmosis, have been replacing tuberculosis as the probable etiologic agent in many cases of granulomatous uveitis.

In the face of such receding popularity, Fine and Flocks6 have recommended the hemagglutination test of Middlebrook and Dubos to support the diagnosis of ocular tuberculosis. Their summary of published reports indicate 75% to 90% positive reactions in pulmonary tuberculosis and 9% to 26% positive titers

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