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July 1960

The Effect of Intraocular Pressure on Outflow Facility

Author Affiliations

Beirut, Lebanon
Department of Ophthalmology, University Hospitals, State University of Iowa.

Arch Ophthalmol. 1960;64(1):125-132. doi:10.1001/archopht.1960.01840010127013

This investigation was prompted by the finding that estimates of outflow facility in the eye of the anesthetized cat varied inversely with the level of intraocular pressure at which they were obtained.1 The evident theoretical and functional significance of this observation warranted its systematic investigation in the enucleated eye, wherein a definitive measure of outflow facility becomes possible.

This publication will report the manner in which this observation was confirmed in the enucleated eye of the rabbit and cat.2

Technique and General Considerations  The eye was carefully enucleated under pentobarbital (Nembutal) anesthesia and immediately transferred to a saline bath at room temperature. The anterior chamber was then cannulated to the servo-perfusor in the manner described in a previous publication.1 Measurements of outflow facility at a steady state were obtained with the constant pressure perfusion technique.Initially, the pressure was maintained at the level of 10 mm. Hg.