In 1922, Meyer1 reported that the serums of certain patients with rheumatoid arthritis agglutinated sensitized sheep erythrocytes. In 1931, Cecil, Nicholls, and Stainsby2 observed the agglutination of β-hemolytic streptococci by the serum of certain patients suffering from rheumatoid arthritis. The suspected etiologic relationship between streptococcal infections and rheumatoid arthritis indicated that the erythrocytes agglutinated because of a precipitin reaction which takes place on the surface of each erythrocyte.3 Because of the variability of preserved sheep erythrocytes Singer and Plotz substituted biologically inert uniform size polystyrene latex particles. With added γ-globulin and mixed with progressive dilutions of the serum to be tested they devised the latex fixation test for rheumatoid arthritis.3 With this technique they found 71.3% positive reactions in serums from patients afflicted by rheumatoid arthritis.
The association of uveitis with rheumatoid arthritis is well documented. Stanworth and Sharp4 found evidence of rheumatoid arthritis in
HALLETT JW, WOLKOWICZ MI, LEOPOLD IH, WIJEWSKI E. Latex Agglutination Test in Uveitis. AMA Arch Ophthalmol. 1960;64(1):133–134. doi:10.1001/archopht.1960.01840010135014
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